A century and a half after the Black Death killed over a third of the population of Western Europe, a new plague swept across the continent. The Great Pox - commonly known as the French disease - brought a different kind of horror: instead of killing its victims rapidly, it endured in their bodies for years, causing acute pain, disfigurement and ultimately an agonising death. In this study three experts explore the impact of the new plague and society's reaction to its challenge. Using a range of contemporary sources, from the archives of charitable and sanitary institutions that coped with the sick to the medical tracts of those that sought to cure it, they provide a detailed account of the experience of the disease across Renaissance Italy, as well as in France and Germany. The authors analyze the symptoms of the Great Pox and the identity of patients, documented in the records of the massive hospital for incurables established in early 16th-century Rome. They show how it challenged accepted medical theory and practice and provoked public disputations among university teachers. And at the most practical level they reveal the plight of its victims at all levels of society, from ecclesiastical lords to the diseased poor who begged in the streets. Examining a range of contexts from princely courts and republics to university faculties, confraternities and hosp-itals, the authors argue for an historical understanding of the Great Pox based on contemporary perceptions rather than a retrospective diagnosis of what later generations came to know as syphilis.