For decades, December 21, 2012, has been a touchstone for doomsayers worldwide. It is the date, they claim, when the ancient Maya calendar predicts the world will end.

In Los Angeles, two weeks before, all is calm. Dr. Gabriel Stanton takes his usual morning bike ride, drops off the dog with his ex-wife, and heads to the lab where he studies incurable prion diseases for the CDC. His first phone call is from a hospital resident who has an urgent case she thinks he needs to see. Meanwhile, Chel Manu, a Guatemalan American researcher at the Getty Museum, is interrupted by a desperate, unwelcome visitor from the black market antiquities trade who thrusts a duffel bag into her hands.

By the end of the day, Stanton, the foremost expert on some of the rarest infections in the world, is grappling with a patient whose every symptom confounds and terrifies him. And Chel, the brightest young star in the field of Maya studies, has possession of an illegal artifact that has miraculously survived the centuries intact: a priceless codex from a lost city of her ancestors. This extraordinary record, written in secret by a royal scribe, seems to hold the answer to her life’s work and to one of history’s great riddles: why the Maya kingdoms vanished overnight. Suddenly it seems that our own civilization might suffer this same fate.

With only days remaining until December 21, 2012, Stanton and Chel must join forces before time runs out.