\"The Heliosphere in the Local Interstellar Medium\", the Proceedings of the First ISSI Workshop 6-10 November 1995, Bern, Switzerland, edited by R. von Steiger, R. Lallement, and M.A. Lee and published in 1996, was the first International Space Science Institute (ISSI) book in the Space Sciences Series. This book covers the knowledge gained in the subsequent 27 years that revolutionized our understanding of the interaction of the heliosphere with the very local interstellar medium (VLISM). Entirely new regions of space have been explored! The Voyagers both crossed the termination shock, passed through the heliosheath, crossed the heliopause, and entered the interstellar medium. New Horizons was launched with more modern instrumentation and explores low-latitude regions of the outer heliosphere. Energetic neutral atoms observed by IBEX and CASSINI allowed exploration of the heliosphere over the whole sky. The initial reconnaissance of the heliosphere and VLISM is complete with in situmeasurements, observations of energetic neutral atoms (ENAs), neutral VLISM H and He, UV emissions, and interstellar dust.\nThis book is a collection reviews from experts in the many aspects of this field that describe the current state of knowledge of the heliosphere’s interaction with the interstellar medium, puzzles yet to be solved, and future plans to continue these studies.