- Contents : History and role of guidelines and guidance for drug evaluation / Jerome Levine -- Decision processes in establishing the efficacy and safety of psychotropic agents / Louis Lasagna -- Design issues for the clinical evaluation of psychotropic drugs / Eugene M. Laska [and others] -- Classification issues in patient selection and description / Jean Endicott [and others] -- Assessment and measurement of clinical change / A. John Rush [and others] -- Pharmacologic considerations / David J. Greenblatt, Darrell R. Abernethy, and Philip Chaikin -- Statistical issues for the clinical evaluation of psychotropic drugs / Philip W. Lavori, Eugene M. Laska, and E.H. Uhlenhuth -- Clinical trial implementation / Ronald Kartzinel [and others] -- Premarketing safety evaluation of psychotropic drugs / Thomas P. Laughren [and others] -- Post-marketing surveillance of drugs / Leo E. Hollister, Judith K. Jones, and Seymour Fisher -- Documenting and reporting the study results of a randomized clinical trial (spicy meatballs, not Pabulum) / David J. Kupfer, Helena C. Kraemer, and John J. Bartko -- Ethical and legal considerations in drug trials / Don Gallant and Susan L. Krinsky -- Evaluating drug treatments of depressive disorders / Gerald L. Klerman [and others] -- Evaluating pharmacologic treatments for bipolar disorder / Alan J. Gelenberg [and others] -- Methods for clinical evaluation of pharmacologic treatments of schizophrenia / John M. Kane [and others] -- Evaluating drug treatments of generalized anxiety disorder and adjustment disorders with anxious mood / Karl Rickels [and others] -- Evaluation of psychotropic drug treatment of panic-related disorders and social phobia / Donald F. Klein [and others] -- Obsessive-compulsive disorder / Wayne K. Goodman [and others] -- Methods for the evaluation of pharmacologic agents in the treatment of cognitive and other deficits in dementia / Samuel Gershon [and others] -- Clinical trials in children and adolescents / Rachel G. Klein [and others] -- Evaluation of pharmacologic treatments in eating disorders / Katherine A. Halmi [and others] -- Evaluation of hypnotic medications / Thomas Roth [and others] -- Establishing the efficacy and safety of medications for the treatment of drug dependence and abuse : methodologic issues / Jack D. Blaine [and others] -- Evaluation of pharmacologic treatments for alcohol abuse, dependence and their complications / Markku Linnoila [and others] -- Evaluation of pharmacologic treatments in personality disorders / Paul H. Soloff [and others].